Endocrine Abstracts

Introduction : Most common cause of rickets is vitamin D deficiency. Genetic mutations in the metabolism and function of Vitamin D is a rarer cause of rickets.Case report : A16 month old male presented with bilateral clavicular swelling, constipation, generalised weakness and poor growth. He also had delay in motor milestones and was only able to sit with support. He was born in the UK to consanguineous parents of Asian origin.Exam...

A 45 year old man was referred to endocrinology with increasing weakness, lethargy, loss of libido and erectile dysfunction. Initial investigations showed hypogonadotrophic hypogonadism with testosterone 0.8 nmol/l (8.2–32.2), FSH <1 U/l, LH<1 U/l, SHBG 93 nmol/l and secondary hypothyroidism with TSH 1.65 mU/l, FT3 2.1 pmol/l FT4 9 pmol/l, prolactin 180 mU/l, IGF-1 12.5 nmol/l. Short synACTHen test showed normal adrenal response (692 to 1014 nmol/l) with a higher ...

Patients with thyroid dysfunction require frequent clinic follow-up, but are often young and have difficulty taking time off work or college, leading to non-attendance and disruption to their treatment. The did not attend (DNA) rate of our endocrine clinic was 21.3%, of whom 44% comprised patients with thyroid disorders. Skype has already been used very successfully for follow-up in the Newham diabetes clinics for our young and ethnically diverse population. We wished to explo...

Aim: To audit outcomes and adherence to prescription recommendations in a nurse-led Diabetic Renal Clinic.Method: Baseline data at time of referral to the clinic was compared to the final clinic visit within a 12-month period (T1) of the first visit (T0), using information from clinic letters and electronic records of patients attending the clinic in our hospital between 2010 and 2014. Patients without at least one follow-up data within a 12-month period...

Background: Somatostatin analogues are the most widely used medical treatment in acromegaly. The available long-acting formulations are administered parenterally (i.m. or deep s.c. injections). Results of a multicentre, baseline controlled, phase 3 study have recently showed that octreotide capsules are an effective and safe treatment in acromegaly. The Treatment Satisfaction Questionnaire for Medication (TQ15M), assessed in the phase 3 study, as exploratory endpoint, compared...

Introduction: A joint ‘late effects’ clinic for follow-up of survivors of childhood cancer has been in operation in our institution since 1995. In patients who have undergone cranial irradiation, dynamic anterior pituitary function testing using a standard insulin tolerance test (ITT) or, if contraindicated, a glucagon or arginine/GHRH test was undertaken at around five yearly intervals.Methods: Case note review was undertaken for 24 patients (...

Background: Treatment of HIV patients with antiretroviral therapies may confer an increased cardiovascular risk, possibly mediated through metabolic perturbations induced by these therapies. We sought to determine whether large arterial stiffening, an early marker and predictor of cardiovascular disease, occurs in HIV recipients of HAART, and if so the plausible mechanisms involved.Methods: In this case-control analysis, 56 HIV subjects (mean age 46 &#17...

Background: Primary aldosteronism is an increasingly recognised cause of hypertension, caused by excess aldosterone secretion. Screening and confirmatory tests such as saline suppression tests (SST) require accurate measurements of aldosterone and use of appropriate cut-offs. Many laboratories have chosen liquid chromatography tandem mass spectrometry (LC-MSMS) methods as issues of poor specificity have been reported for immunoassay methods. During the validat...

Introduction: The diagnosis of central hypothyroidism can be challenging and confused with other causes of low thyroxine concentrations without TSH elevation. The response of the thyroid hormone axis before and after treatment is reported in children with Central Hypothyroidism [CH] as part of an exercise aimed at validating free thyroxine reference ranges.Methods: Roche Elecsys Cobas TSH and FT4 immunoassays were used. ...

Background and Aim: Approximately 1500 people attend the Beacon Health Check Department annually involving a panel of blood tests being screened. Our aim was to compare what percentage of this asymptomatic population have diabetes or were pre-diabetic and what percentage of these were undiagnosed and therefore untreated conditions.Methodology: This audit was a retrospective review of data collected from patients attending the Beacon Hospital Health Check...